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Journal Article 1

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2023 1

Keywords

ADAM10 inhibitor 1

Barrier disruption 1

Host-directed therapy 1

Kaempferol 1

Necroptosis 1

Staphylococcus aureus infection 1

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Discovery of Kaempferol, a Novel ADAM10 Inhibitor, as a Potential Treatment for Staphylococcus aureus Article

Tingting Wang, Jianfeng Wang, Xiangzhu Xu, Fan Jiang, Hongfa Lv, Qinghui Qi, Can Zhang, Qianghua Lv, Xuming Deng

Engineering 2023, Volume 28, Issue 9,   Pages 206-221 doi: 10.1016/j.eng.2023.03.006

Abstract: Using a fluorogenic substrate assay, we further identified kaempferol as a potent ADAM10 inhibitor thatCollectively, our work presents a novel hostdirected therapeutic strategy for using the promising candidate kaempferol

Keywords： Host-directed therapy     Kaempferol     ADAM10 inhibitor     Staphylococcus aureus infection     Barrier disruption    

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Discovery of Kaempferol, a Novel ADAM10 Inhibitor, as a Potential Treatment for Staphylococcus aureus

Tingting Wang, Jianfeng Wang, Xiangzhu Xu, Fan Jiang, Hongfa Lv, Qinghui Qi, Can Zhang, Qianghua Lv, Xuming Deng

Journal Article